Botox vs. Xeomin: What's the Difference and Which One Is Right for You?
- 1 day ago
- 2 min read

If you've been getting Botox for a while, you've probably heard of Xeomin. And if you haven't started yet, you might be wondering why there are two options in the first place.
The short answer: they do the same thing.
The difference is in the formulation. Whether that matters to you depends on a few things.
Here's the breakdown.
What they have in common
Both Botox and Xeomin are FDA-approved neurotoxin injectables.
Both temporarily relax the facial muscles responsible for expression lines (the ones that cause forehead lines, frown lines between the brows, and crow's feet around the eyes.)
Both take three to seven days to show results and last three to four months on average.
Both are dosed in units and priced the same way.
For most clients, the experience of getting either one is essentially identical.
So what's actually different?
The difference comes down to what's in the formula besides the active neurotoxin.
Botox contains accessory proteins which are additional proteins that surround the active botulinum toxin molecule. These proteins don't do anything to your face. They're part of how the product is manufactured and stabilized.
Xeomin doesn't have them. It's sometimes called a "naked" neurotoxin because it contains only the active ingredient with no additives. No accessory proteins, no extras.
Why does that matter?
For most people, it doesn't. Both products work well and the accessory proteins in Botox are not harmful.
The reason Xeomin comes up is this: with any injectable protein, there's a small possibility your immune system develops antibodies to it over time. For a small subset of long-term Botox users, this can result in the product becoming less effective requiring more units to achieve the same result, or the result not lasting as long.
Because Xeomin contains fewer proteins, some providers and patients find it's a useful alternative when someone feels their current toxin has plateaued. It's not a guaranteed fix, but it's a real reason some clients switch.
Which one should you choose?
If you're new to neurotoxin, either one is a fine starting point. Most providers have a preference based on their experience and your anatomy. Ask them.
If you've been getting Botox for years and feel like it's not working as well as it used to, Xeomin is worth a conversation.
If you're happy with what you're getting, there's no reason to change.
The goal with both is the same: softer lines, a more rested appearance, and a face that still looks like yours.
Not frozen.
Not overdone.
Just you on a good day.
What we offer at Graceology
Both Botox and Xeomin are available at Graceology Med Spa in Overland Park. Your provider will recommend one based on your history and goals and if you have a preference, say so.



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